Highlights in Translational Science

Kliniker und Forscher betrachten die neuesten Fortschritte in der Grundlagenwissenschaft, in Tiermodellen, bei den Folgeerkrankungen und den Behandlungsmöglichkeiten im Hinblick auf die Myopie aus ihren verschiedenen Blickwinkeln, sodass diese sich sinnvoll ergänzen. Ziel ist es, den Dialog zwischen Klinikern und Wissenschaftlern weiter anzuregen, um dieses wichtige Forschungsgebiet voranzubringen. 

 
engl
Saal 3 08:30 - 09:45 10.10.2020
Symposien Sa06
Highlights in Translational Science - Hot topics in myopia research – Symposium des AK DOG-Forschung
From a global perspective, the prevalence of myopia is increasing worldwide, putting individuals, in particular children and adolescents, at risk for visual disability later in life. While several interventions for myopia control have already entered into clinical routine over the last years, their mode of action as well as the underlying pathophysiology are yet far from being understood. This symposium shall educate on the latest advances in basic science, animal models, secondary diseases and treatment options with regard to myopia. It shall further stimulate the dialogue among clinicians and scientists to advance this important field of research. It builds upon and continues the well attended 2019 DOG Symposium on Hot topics in myopia research.
Wolf Lagrèze (Freiburg)
Frank Schaeffel, Sektionsleiter (Tübingen)
Wim Quint (Rotterdam)

While SNPs close to GJD2 have been consistently found to influence the risk of refractive error, evidence for functional involvement was still needed. To investigate the pathophysiological link between an altered GJD2 / connexin 36 expression and refractive error, we evaluated the axial length, refractive state, and electrophysiology of gjd2a and gjd2b deficient zebrafish. In the gjd2a mutant, we found an altered axial length, refractive error, and b-wave amplitude, while the gjd2b mutant showed a cataract phenotype.

Machelle Pardue (Atlanta)
Focke Ziemssen, Stellvertretung des ärztlichen Direktors (Tübingen)
Chi-Ho To (Hong Kong)

Eye growth in animals is known to be driven by optical defocus. Our work has demonstrated that the eye is able to integrate simultaneously presented optical defocus and use the information to guide its growth. Applying this principle, we have devised a number of new optical methods for controlling  myopia in children. The results showed that similar principle is at work in human and that optical defocus can effectively slow down eye growth and control myopia in children.